Cyclo-oxygenase-2 (COX-2) expression at the site of recent myocardial infarction: friend or foe?

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Cyclo-oxygenase-2 (COX-2) expression at the site of recent myocardial infarction: friend or foe?

BACKGROUND Cyclo-oxygenase-2 (COX-2) is induced in cardiomyocytes only in response to stress, such as ischaemia. OBJECTIVE To assess COX-2 expression at the site of recent myocardial infarction. METHODS COX-2 expression was evaluated by specific immunostaining in cardiomyocytes from 23 subjects who died 10-60 days after acute myocardial infarction. The relation between COX-2 myocardial expr...

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BASIC RESEARCH Cyclo-oxygenase-2 (COX-2) expression at the site of recent myocardial infarction: friend or foe?

Background: Cyclo-oxygenase-2 (COX-2) is induced in cardiomyocytes only in response to stress, such as ischaemia. Objective: To assess COX-2 expression at the site of recent myocardial infarction. Methods: COX-2 expression was evaluated by specific immunostaining in cardiomyocytes from 23 subjects who died 10–60 days after acute myocardial infarction. The relation between COX-2 myocardial expre...

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Correspondence to: Mr Sean Turner, Clinical Services, Princess Margaret Hospital, Roberts Road, Perth, Western Australia 6008, Australia; sean.turner@health. wa.gov.au _________________________ T here has been a great deal written about the use of selective cyclo-oxygenase-2 (COX-2) inhibitors in the adult population. Yet despite this there is still controversy over their place in treatment and...

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ژورنال

عنوان ژورنال: Heart

سال: 2004

ISSN: 0007-0769

DOI: 10.1136/hrt.2003.010280